Tapinarof Validates the Aryl Hydrocarbon Receptor as a Therapeutic Target: A Clinical Review

The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription issue that has wide-ranging roles, together with regulation of irritation and homeostasis. AhR just isn’t a cell-surface receptor however exists in a cytoplasmic advanced that responds to all kinds of structurally dissimilar endogenous, microbial, and environmental ligands. The ever-present expression of AhR, its skill to be activated by a variety of ligands, and its capability to behave as a grasp regulator for gene expression and homeostasis make it a promising new therapeutic goal.

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