Similarities and Differences in Peripheral Itch and Pain Pathways in Atopic Dermatitis

Atopic dermatitis (AD) is predominantly characterised by intense itching, however concomitant pores and skin ache is skilled by greater than 40% of sufferers. Sufferers with AD show appreciable somatosensory aberrations together with elevated nerve sensitivity to itch stimuli (hyperknesis), notion of itch from innocuous stimuli (alloknesis), or notion of ache from innocuous stimuli (allodynia). This overview summarizes the present understanding of the similarities and variations within the peripheral mechanisms underlying itch and ache in atopic dermatitis.

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