A brand new examine revealed in The New England Journal of Medicine has proven that use of semaglutide, a drug used for the therapy of diabetes and weight administration, lowered cardiovascular occasions by 20% in adults with heart problems and obese or weight problems who didn’t have diabetes.
The examine included over 17,600 sufferers who had heart problems and a physique mass index higher than or equal to 27 however who had no historical past of diabetes. Half of the members obtained a once-weekly dose of semaglutide whereas the opposite half obtained placebo. Individuals obtained semaglutide or placebo for a median of 34 months, with a median follow-up time of virtually 40 months. Throughout that point, members had been monitored for cardiovascular occasions together with loss of life attributable to cardiovascular causes, non-fatal coronary heart assaults, and non-fatal strokes.
The outcomes confirmed that cardiovascular occasions occurred in 6.5% of the sufferers taking semaglutide and in 8.0% of the sufferers taking placebo. This important distinction represented a 20% lower in relative threat of cardiovascular occasions for these taking semaglutide. Along with this discount in threat, sufferers within the semaglutide group misplaced a median of 9.4% of their physique weight and confirmed enhancements in frequent threat elements for coronary heart illness.
An writer of the examine noted that whereas obese and weight problems are recognized threat elements for coronary heart illness, the usual observe for addressing heart problems is to deal with different threat elements reminiscent of ldl cholesterol, blood strain, and diabetes. That is the primary examine to indicate that treating weight immediately by a pharmaceutical intervention may also scale back the chance of cardiovascular occasions. Efficient remedies for weight administration have traditionally been comparatively restricted, probably attributable to biases and perceptions surrounding weight. Nonetheless, this trial and its outcomes present that treating weight immediately seems to have promising results on heart problems.
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