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Population Pharmacokinetic/Pharmacodynamic Analysis Of Garadacimab, In Patients With Hereditary Angioedema

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Garadacimab (anti-activated issue XII monoclonal antibody) is being evaluated for long-term prophylaxis of hereditary angioedema (HAE). Inhibition of FXIIa-mediated kallikrein exercise can be utilized as a measure of garadacimab impact. We assessed the pharmacokinetic (PK)/pharmacodynamic (PD) relationship between garadacimab focus and FXIIa-mediated kallikrein exercise, and the influence of intrinsic/extrinsic components in inhabitants subgroups.

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