Novel Bradykinin Detection In The Diagnostic Workup Of Patients With Recurrent Angioedema Attacks

Recurrent angioedema etiology will be bradykinin-mediated angioedema (BK-AE) or extra generally by mast cell activation. Nonetheless, BK-AE will be doubtlessly deadly if acute laryngeal signs are undiagnosed or untreated. Establishing a constant diagnostic measurement of bradykinin for recurrent angioedema sufferers can distinguish between the 2 pathways, offering optimized remedy. The research objective was to make use of liquid chromatography-tandem mass spectrometry (LC-MS/MS) to quantitatively measure bradykinin and detect variations between sufferers with Hereditary Angioedema (HAE) versus non-histaminergic idiopathic angioedema (IAE) and Hereditary Angioedema with regular C1-Inhibitor (HAE-nl-C1INH) sufferers.

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