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Janus kinase 1 (JAK1) is essential for sort 2 cytokine signaling, and gain-of-function JAK1 mutations are related to a number of persistent allergic issues. Tamari et al (Cell 2024;187:44-61.e17; https://doi.org/10.1016/j.cell.2023.11.027) examined the tissue-specific immunoregulatory roles of JAK1 signaling. Spontaneous allergic irritation was noticed within the pores and skin, however not the lungs, of mice containing a pathogenic human JAK1 gain-of-function variant. Furthermore, the JAK1 gain-of-function variant protected towards allergen-induced airway irritation.

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