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Deng et al (Cell 2023;186:5375-93.e25; https://doi.org/10.1016/j.cell.2023.10.019) recognized an necessary function for direct activation of neurons by pores and skin microbes in itch technology. Extra particularly, epicutaneous publicity to Staphylococcus aureus induced itch- and scratch-induced pores and skin injury in mice. Mechanistically, S aureus secreted a serine protease, V8, which induced direct cleavage of proteinase-activated receptor 1 (PAR1) current on the floor of sensory neurons that mediate itch. Lastly, PAR1 genetic deficiency or pharmacologic inhibition led to decreased S aureus-induced itch.

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