Navigating the blurred path of mixed neuro-immune signaling

Evolution has created complicated mechanisms to sense environmental hazard and shield tissues, with the nervous and immune methods enjoying pivotal roles. These methods work collectively, coordinating native and systemic reflexes to revive homeostasis in response to tissue damage and an infection. By sharing receptors and ligands, they affect the pathogenesis of assorted ailments. Lately, a much less explored facet of neuro-immune communication has emerged: the discharge of neuropeptides from immune cells and cytokines/chemokines from sensory neurons.

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