Inborn errors of immunity reveal the molecular requirements for the generation and maintenance of human IL-9 expressing cells.

CD4+ T cells play important roles in adaptive immunity. Distinct CD4+ T cell subsets – Th1, Th2, Th17, Th22, T follicular helper and regulatory T cells – have been recognized and their contributions to host defence and immune regulation are more and more well-defined. IL-9 producing Th9 cells had been first described in 2008 and seem to play each protecting and pathogenic roles in human immunity. Nonetheless, key necessities for producing human Th9 cells stay incompletely outlined.

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