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Impaired interferon response in plasmacytoid dendritic cells from children with persistent wheeze

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Respiratory wheeze is distinguished in early childhood, with as much as 50% of youngsters experiencing an episode of wheeze throughout the first 6 years of life.1,2 Respiratory wheeze usually happens in response to viral respiratory tract infections attributable to frequent viruses resembling respiratory syncytial virus and rhinovirus (RV).3-5 The severity of wheezing episodes varies from delicate to extreme and might require emergency medical consideration. Normally, childhood wheezing is transient and resolves by itself. Nevertheless, a subset of youngsters develops a recurrent wheezing exacerbation phenotype that develops into bronchial asthma.

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