Biologic and Small Molecule Therapy for Treating Moderate to Severe Atopic Dermatitis: Mechanistic Considerations

Atopic dermatitis (AD) is a posh and heterogeneous pores and skin illness the place attaining full medical clearance for many sufferers has confirmed difficult by means of single cytokine inhibition. Present research combine biomarkers and consider their position in AD, aiming to advance our understanding of the various molecular profiles implicated. Whereas historically characterised as a Th2-driven illness, intensive analysis has just lately revealed the involvement of Th1, Th17, and Th22 immune pathways, in addition to the interaction of pivotal immune molecules, resembling OX40, OX40 ligand (OX40L), thymic stromal lymphopoietin (TSLP), and IL-33.

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