Many people wished to get a COVID-19 vaccine as quickly because it was out there, and went to get further COVID-19 vaccine pictures and boosters after they grew to become out there. However no less than one individual on the market took that precaution to a wild excessive, by receiving what they declare was 217 COVID-19 vaccine doses; of these, 134 have been formally confirmed, which remains to be an astonishing variety of pictures. Researchers realized of this case from media studies, and reached out to the person to see in the event that they had been fascinated about being the topic of some scientific investigations. The individual, who had gotten a number of doses of eight completely different vaccines, agreed to the research; the findings have been reported in The Lancet Infectious Disease.
The research authors have cautioned that this report solely contains knowledge from one individual, so it’s not indicative of what may occur to others in the identical state of affairs. Some researchers have thought that an extreme variety of vaccine doses would truly impair the immune system, however this analysis confirmed that the individual’s immune system has remained completely practical. Additionally they carry significantly excessive ranges of sure antibodies in opposition to the virus that causes COVID-19, SARS-CoV-2, in comparison with individuals who have had three doses of the vaccine.
Vaccinations are supposed to prime the immune system; they expose it to a small little bit of a pathogen in order that the immune system will generate antibodies in opposition to that pathogen. Then if there may be an publicity, the immune system is already ready to battle the pathogen with present antibodies.
However in some persistent infections that may flare up chronically, like HIV or hepatitis B, some immune cells might turn into worn out and begin releasing decrease ranges of drugs that promote irritation, and battle an infection, defined corresponding research creator Dr. Kilian Schober of FAU.
This research has instructed that repeated publicity to SARS-CoV-2 vaccines might not have the identical impact on the immune system as these different viruses, nevertheless.
The researchers had been capable of assess a number of samples taken from the hypervaccinated particular person all through the interval wherein the doses had been acquired. A few of them had been frozen blood samples. The investigators additionally took new samples. The investigators discovered that there have been excessive ranges of T-effector cells that may battle SARS-CoV-2. There was additionally no indication of fatigue in these effector cells.
The scientists examined reminiscence T cells on this affected person, which might replenish effector cells. There have been simply as many reminiscence T cells within the affected person as in management circumstances.
“General, we didn’t discover any indication for a weaker immune response, slightly the opposite,” added research co-author Katharina Kocher.
Moreover, the immune system was additionally simply as efficient in opposition to different pathogens. Hypervaccination didn’t harm this individual’s immune system, and it has additionally instructed that the mRNA vaccines are quote tolerable.
Nevertheless, there may be additionally no indication that folks ought to get additional COVID-19 vaccinations if they don’t seem to be really useful for his or her age group or by their healthcare supplier. A 3-dose collection (not 200) with common boosters remains to be really useful for many adults.
Sources: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), The Lancet Infectious Diseases
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