This assessment article summarizes and feedback on the mechanistic work on kind 2 immunity revealed between January 2022 and September 2024. Sort 2 immunity is characterised by the manufacturing of IL4, IL5, IL9 and IL13, and primarily identified for its detrimental roles in allergic ailments and protecting roles in helminth infections. Different features of kind 2 immunity embrace safety in opposition to venoms and toxins, wound therapeutic, tissue transforming, regeneration and metabolic homeostasis. This assessment article discusses novel findings on regulation of those processes and illness states by choose cells and humoral components of kind 2 immunity, together with group 2 innate lymphoid cells (ILC2s), CD4 T cells, mast cells, peripheral neurons and IgE.
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