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Update on Mast Cell Biology

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Mast cells (MCs) are heterogeneous tissue-resident effector cells thought to play central roles in allergic inflammatory illness, but the diploma of heterogeneity and nature of those roles has remained elusive. Lately, advances in tissue tradition techniques, pre-clinical mouse fashions, and the continued unfold of single-cell RNA sequencing has tremendously superior our understanding of MC phenotypes in well being and illness. These approaches have recognized novel interactions of MC subsets with immune cells, neurons, and tissue structural cells, altering our understanding of how MCs each drive and assist resolve tissue irritation, reshape tissue microenvironments, and affect host habits.

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