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Type 2 T-Helper Cell Driven Manifestations of Inborn Errors of Immunity

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Monogenic lesions in pathways important for effector features chargeable for immune surveillance, safety towards autoinflammation and applicable responses to allergens and microorganisms underlie the pathophysiology of inborn errors of immunity (IEI). Variants in cytokine manufacturing, cytokine signaling, epithelial barrier operate, antigen presentation, receptor signaling, and mobile processes and metabolism can drive autoimmunity, immunodeficiency and/or allergic irritation. Identification of those variants have improved our understanding of the position that many of those proteins play in skewing in the direction of Th2 associated allergic irritation.

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