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TL1A: a novel alarmin in airway, intestinal, and autoimmune disorders

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The time period alarmin denotes a broad class of molecules quickly launched to alert the immune system by way of the engagement of particular receptors on immune cells. Three alarmin cytokines, thymic stromal lymphopoietin (TSLP), IL-33, IL-25), are launched from epithelial and sure stromal cells. TNF-like cytokine 1A (TL1A) is a member of the TNF cytokine superfamily, first recognized in human endothelial cells. TL1A is now thought of a novel alarmin expressed by human and mouse bronchial and intestinal epithelial cells.

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