Thymic pioneers: Charting the origin, identity and fate of human thymus seeding progenitors

T cells develop within the specialised microenvironment of the thymus however originate from hematopoietic stem cells within the bone marrow. Significantly in human, the identification and traits of the precursor cells that journey by way of the circulation to seed the thymic tissue stays a matter of debate, and the hematopoietic lineage potential and eventual intrathymic differentiation trajectories haven’t been absolutely outlined. As well as, the mechanisms regulating the homing and entry course of within the thymus are largely unclear however might have essential translational implications for thymic rejuvenation and environment friendly T cell technology in immunocompromised people.

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