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Therapeutic Effect of Azithromycin on Neutrophilic Asthma

Azithromycin (AZ), which is efficient to decreasing bronchial asthma exacerbations, and enhancing lung operate and high quality of life, is really useful as an add-on remedy in sufferers with extreme bronchial asthma (SA). Though it’s recognized that neutrophilic airway irritation is related to bronchial asthma severity and treatment-resistance in asthmatics, the impact of AZ on neutrophilic bronchial asthma (NA) has not been clarified. Our latest research has proven that the deficiency of otulin contributes to the event of neutrophilic irritation by inducing IL-1β overproduction and NLRP3 inflammasome activation in macrophages and airway epithelial cells (AECs).

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