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Neutrophilic dermatoses are a category of uncommon and poorly understood inflammatory pores and skin ailments that features Candy syndrome and pyoderma gangrenosum. On this problem, Cavagnero et al (p 966) profiled the mobile and molecular panorama of Candy syndrome pores and skin and contrasted it with pyoderma gangrenosum and wholesome controls. Utilizing single-nucleus and bulk RNA sequencing of archival biopsies, complemented by spatial transcriptomics, the authors recognized a strong sort I interferon signature that was strongly enriched in Candy syndrome however diminished in pyoderma gangrenosum and absent in controls.

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