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Mounting proof means that elevated airway tissue eosinophilia is a function of the pathobiology of bronchial asthma with comorbid weight problems. This noticed submucosal eosinophilia in airway biopsies usually doesn’t correlate with blood, sputum, or bronchoalveolar lavage fluid eosinophil counts. The mechanisms directing the retention and accumulation of airway eosinophils in bronchial asthma with weight problems are unknown. On this challenge, Ingram et al (p 819) hypothesized that airway structural cells produce extra eotaxin, a potent eosinophil chemoattractant, in response to the mixed excessive ranges of leptin and IL-13 in allergic bronchial asthma with comorbid weight problems.

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