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Though many preschool youngsters expertise wheezing, just some go on to develop bronchial asthma. On this challenge, Macowan et al (p 94) aimed to know the molecular mechanisms behind this transition. The authors performed a complete multi-omic evaluation of decrease airway samples, bronchial brushings, and bronchoalveolar lavage fluid from preschool youngsters with recurrent wheeze, school-aged asthmatic youngsters, and wholesome controls. Superior methods comparable to microbial shotgun metagenomics, metatranscriptomics, host gene expression profiling, and metabolomics/lipidomics have been employed to look at host and microbial molecular signatures.

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