Tezepelumab inhibits highly functional truncated thymic stromal lymphopoietin in chronic rhinosinusitis

Thymic stromal lymphopoietin (TSLP) and its practical cleavage merchandise are elevated in nasal polyps (NPs) and play necessary roles in sort 2 (T2) irritation in persistent rhinosinusitis (CRS) with NPs (CRSwNP) by activating myeloid dendritic cells (mDCs) and group 2 innate lymphoid cells (ILC2s). Nevertheless, whether or not tezepelumab, a human monoclonal antibody in opposition to TSLP, inhibits practical cleaved TSLP and the function of TSLP in CRS with out NPs (CRSsNP) haven’t been studied.

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