T, B, and NK cells versus the primary immunodeficiency orientation tube for diagnostic screening of IEIs

Stream cytometric quantification of the foremost populations of peripheral blood lymphocytes is vital within the diagnostic screening of inborn errors of immunity (IEIs).1,2 Nevertheless, no consensus exists in regards to the degree of element required on the lymphocyte inhabitants degree. Evaluation of whole, CD4 and CD8 PB T-cell ranges, and whole B- and pure killer (NK) cell ranges by way of mixed evaluation of CD3, CD4, CD8, CD19, and CD56 is broadly recommended3 for the screening of extreme mixed immunodeficiency (SCID), nonsevere mixed immunodeficiency (CID), predominantly antibody deficiency (PAD), and illnesses of immune dysregulation (DIDs), and it’s used at many reference facilities.

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