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The isolation and enlargement of uncommon and ultra-rare cell populations are essential for advancing cell remedy manufacturing. For instance, Foxp3-positive naïve regulatory T cells (nTregs) – which play a key function in the induction of self-tolerance and the management of autoimmunity–could account for less than 0.5 % of a pattern containing one billion leukocytes, making it extraordinarily difficult to isolate these cells with excessive purity.
The CGX10 Cell Isolation System from Sony Biotechnology is a strong closed cell sorter designed for terribly quick isolation of ultra-rare cells with excessive purity. The system’s Enrichment Mode provides fast goal cell isolation from extremely concentrated samples–processing as much as 100,000 occasions per second–whereas Purity Mode can obtain a purity of as much as 97% whereas sorting cells at as much as 15,000 occasions per second.
Our newest utility word particulars a groundbreaking strategy utilizing these modes in tandem for sterile, excessive throughput isolation of Foxp3-positive nTregs on the CGX10 Cell Isolation System. This step-by-step protocol saves time and assets by bypassing bead-based pre-enrichment steps, continuing on to stream cytometry-based cell isolation for environment friendly cell remedy manufacturing.
Key advantages of the CGX10 Cell Isolation System for sorting ultra-rare populations of cells:
- GMP-compliant – for cell and gene remedy manufacturing environments
- Environment friendly sorting – enriches and purifies nTregs from one billion leukocytes in lower than 5 hours
- Enrichment Mode – appropriate for pre-purifying uncommon and ultra-rare cell populations (<0.5% goal in beginning pattern)
- Purity Mode – achieves isolation with 97% purity
- Tandem sorting protocol – allows isolation of extremely pure, viable, and expandable nTregs
- Sterile – allows reusing the identical Sterile Tubing Package to attain excessive closing purity
- Environment friendly sorting straight from leukopaks – removes the necessity for pre-enrichment steps
Learn our utility word to study extra about sorting ultra-rare T cells straight from leukopaks utilizing the CGX10 Cell Isolation System.
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