STING stimulates recruitment of inflammatory cells and airway fibrosis in chronic allergic airway inflammation

Publicity of the airways to allergenic extracts stimulates Toll-like receptor 4 (TLR4)-mediated oxidative DNA injury within the lungs, which in flip promotes allergic lung irritation.1 Double-stranded DNA breaks improve home mud mite (HDM)-induced TH2 cytokine secretion from bronchial epithelial cells.2 The endoplasmic reticulum protein stimulator of interferon genes (STING) is an adaptor for the intracytoplasmic DNA sensor protein cyclic GMP-AMP synthase (cGAS). Activation of the STING pathway is triggered by cytoplasmic DNA launched throughout mobile stress.

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