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Role of APE1 Redox Function in Chronic Rhinosinusitis Pathogenesis: Implications for Targeted Therapy

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Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional enzyme with two distinct features – endonuclease exercise in its C-terminal area and redox operate in its N-terminal area. The redox exercise of APE1 regulates a subset of transcription elements concerned in cell survival, angiogenesis, and irritation. Nevertheless, its function in persistent rhinosinusitis with nasal polyps (CRSwNP) are usually not absolutely understood.

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