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We thank Franceschini et al1 for his or her feedback on our debate inspecting the function of IgG4 in eosinophilic esophagitis (EoE),2 and we have an interest to listen to of extra sufferers with EoE and comorbid IgG4 deficiency. We agree that this scientific statement means that IgG4 isn’t essential for EoE pathogenesis. We acknowledge, nonetheless, that there are distinct phenotypes and endotypes of EoE and different gastrointestinal ailments. For instance, Lee et al lately discovered that IgG4 staining within the tissue is larger in sufferers with the blended inflammatory and fibrostenotic EoE phenotype.

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