We’re grateful for the instructive correspondence from Gabers and Werfel, which questioned the appropriateness of utilizing IL6R genetic variation to approximate the consequences of therapeutic IL-6 receptor (IL-6R) inhibition.1 We agree with, and certainly have highlighted,2 the necessity for additional analysis to analyze the consequences of selective versus international IL-6R inhibition. We additionally agree that our strategy has limitations, together with many past this particular criticism, however we want readers to think about the next protection.
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