We thank Drs Rank1 and Ledoult and colleagues2 for his or her curiosity in and response to our article “Mepolizumab incompletely suppresses medical flares in a pilot research of episodic angioedema with eosinophilia.”3 Each of those communications increase vital questions concerning the prognosis and pathogenesis of this uncommon dysfunction, and we recognize the chance to additional focus on our understanding of this situation.
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