We’ve learn with curiosity the gripping feedback by Wang et al1 regarding our article2 evaluating genetic variants in atopy-related genes in nonsteroidal anti-inflammatory drug (NSAID)–induced acute urticaria/angioedema. We agree that it’s essential to transcend the associations described in our observational case-control research and that useful analysis must be assessed in future research (perhaps via ex vivo assays, such because the basophil activation take a look at and leukotriene launch). Nevertheless, some doubts come up regarding basophil activation take a look at utility in such analysis.
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