We admire Lazarowitz et al for his or her well timed response to our evaluation on using Bruton tyrosine kinase inhibitors (BTKis) in allergic issues, given the current approval of remibrutinib by the US Meals and Drug Administration (FDA) for therapy of antihistamine-refractory power spontaneous urticaria.1 Their letter proposes 2 fascinating mechanisms for the section III REMIX-1/REMIX-2 trial findings of elevated delicate petechiae occasions in sufferers receiving remibrutinib.2
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