Recapitulating primary immunodeficiencies with expanded potential stem cells: Proof of concept with STAT1 gain of function

Inborn errors of immunity (IEI) usually lack particular illness fashions and personalised administration. Sign transducer and activator of transcription (STAT)-1 acquire of operate (GoF) is such an instance of an IEI with various medical phenotype with unclear pathomechanisms and unpredictable response to remedy.1-3 First described in 2011 as an autosomal-dominant power mucocutaneous candidiasis (CMC) illness, the spectrum of STAT1-GoF manifestations and severity varies tremendously, even amongst relations harboring the identical germline mutation.

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