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Adeno-associated virus (AAV) is a outstanding methodology for delivering genes in vivo. Therapeutic supply to focus on cells is achieved via full capsids containing the gene cargo. Nonetheless, the presence of empty capsids within the AAV drug product can scale back therapeutic effectiveness, necessitating their detection at numerous phases of the AAV manufacturing course of. Conventional strategies for assessing the AAV empty/full (E/F) ratio are sometimes sluggish, labor-intensive, and require vital optimization.
Take into account a novel, speedy, and high-throughput method for figuring out the AAV E/F ratio utilizing Octet® Biolayer Interferometry (BLI) alongside Octet® AAVX Biosensors. This cutting-edge approach evaluates intact viral capsids and is ideal for screening each crude and purified samples, providing a faster and extra environment friendly workflow with outcomes accessible in as little as half-hour.
Uncover the benefits of this revolutionary methodology and improve your AAV workflow by downloading the technical word.
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