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Adeno-associated virus (AAV) is a distinguished technique for delivering genes in vivo. Therapeutic supply to focus on cells is achieved via full capsids containing the gene cargo. Nevertheless, the presence of empty capsids within the AAV drug product can cut back therapeutic effectiveness, necessitating their detection at numerous levels of the AAV manufacturing course of. Conventional strategies for assessing the AAV empty/full (E/F) ratio are sometimes gradual, labor-intensive, and require important optimization.
Think about a novel, fast, and high-throughput method for figuring out the AAV E/F ratio utilizing Octet® Biolayer Interferometry (BLI) alongside Octet® AAVX Biosensors. This cutting-edge method evaluates intact viral capsids and is ideal for screening each crude and purified samples, providing a faster and extra environment friendly workflow with outcomes out there in as little as half-hour.
Uncover the benefits of this modern technique and improve your AAV workflow by downloading the technical observe.
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