IgE and mast cells play key roles within the pathophysiology of allergic illnesses, and omalizumab was the primary monoclonal anti-IgE antibody licensed within the U.S. when initially FDA-approved for the remedy of allergic bronchial asthma in 2003. Since that point, the variety of FDA-approved indications for remedy with omalizumab has grown to incorporate persistent spontaneous urticaria, persistent rhinosinusitis with nasal polyps, and meals allergy. Though omalizumab is mostly thought of comparatively secure and well-tolerated, numerous security considerations have been raised since its preliminary approval.
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