Novel Insights on the Biology and Immunological Effects of Histamine: A Road Map for Allergists and Mast Cell Biologists

Histamine (C5H9N3, molecular weight 111.15 g/mol) is a well-studied endogenous biogenic amine composed of an imidazole ring connected to an ethylamine facet chain. It has a restricted half-life of some minutes inside tissues and in circulation. A number of cell varieties together with mast cells (MCs), basophils, platelets, histaminergic neurons, and enterochromaffin cells produce various quantities of histamine utilizing histidine decarboxylase (HDC). Nevertheless, solely MCs and basophils have complicated mechanisms to pack and retailer histamine in granules together with different mediators utilizing serglycin and its carried glycosaminoglycan (GAG) facet chains.

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