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Wang et al (Nat Med 2025 Jan 7; https://doi.org/10.1038/s41591-024-03419-3) carried out a placebo-controlled, randomized, part 3 trial to judge the security and efficacy of suraxavir marboxil, an oral inhibitor of influenza polymerase acidic protein (PA), in acute uncomplicated influenza. Practically 600 outpatients aged 5 to 65 years got a single dose of suraxavir or placebo inside 2 days of symptom onset. Suraxavir decreased the median time to alleviation of signs by over 20 hours and decreased viral load inside 24 hours as in comparison with placebo.

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