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Mast cells are necessary contributors to allergic airway irritation. Alhallak et al (Immunity 2024;57:1274-88.e6; https://doi.org/10.1016/j.immuni.2024.05.003) uncovered a novel protecting position for mast cells by limiting IL-33 signaling. Extra particularly, prostaglandin E2 (PGE2) and mast cell-specific expression of E prostanoid (EP2) receptor have been required for optimum manufacturing of the IL-33 decoy receptor soluble suppressor of tumorigenicity 2 (sST2) inside the lung. Intraepithelial mast cells have been recognized because the predominant supply of sST2 within the lung.

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