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Nemolizumab is a mAb that inhibits the signaling of the neuroimmune cytokine IL-31, which promotes irritation and pruritus in atopic dermatitis. Silverberg et al (Lancet 2024;404(10451):445-60; https://doi.org/10.1016/S0140-6736(24)01203-0) performed 2 randomized, placebo-controlled part 3 medical trials (ARCADIA 1 and a couple of) to evaluate the security and efficacy of nemolizumab in grownup and adolescent sufferers with moderate-to-severe atopic dermatitis. Nemolizumab improved pores and skin clearance, sleep disturbance, and pruritus after 16 weeks of remedy as in comparison with placebo in each trials.

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