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Due to the inefficiency related to conventional strategies of antibody discovery, Wasdin et al (Cell 2025 Nov 4:S0092-8674(25)01135-3; https://doi.org/10.1016/j.cell.2025.10.006) developed an amino acid sequence-based protein language mannequin, named Monoclonal Antibody Generator (MAGE), that creates paired heavy and light-weight chain antibody sequences that particularly bind enter antigens with no beginning design template. MAGE effectively generated a various repertoire of antibodies, together with neutralizing antibodies towards a number of respiratory viruses, together with SARS-CoV-2, avian influenza H5N1, and respiratory syncytial virus A (RSV-A) that had been experimentally validated in vitro.

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