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Peripheral regulatory T cells (pTregs) are important for peripheral tolerance, however the mobile mechanisms underlying their induction should not solely recognized. Rudnitsky et al (Nature 2025;644:231-40; https://doi.org/10.1038/s41586-025-09173-x) recognized that RORγt+ antigen-presenting cells (APCs), slightly than typical kind I dendritic cells (cDC1s), provoke the technology of food-specific pTregs. cDC1s have been discovered to drive food-specific CD8αβ T-cell responses, which have been blocked by pTregs throughout homeostasis to keep up oral tolerance.

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