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Dupilumab is an mAb that blocks the signaling of each IL-4 and IL-13. Bhatt et al (Lancet Respir Med 2025 Jan 31; https://doi.org/10.1016/S2213-2600(24)00409-0) performed a pooled evaluation of over 1800 topics from 2 randomized, placebo-controlled section 3 trials (BOREAS and NOTUS) that evaluated the security and efficacy of dupilumab in grownup sufferers with continual obstructive pulmonary illness (COPD) and proof of kind 2 irritation (blood eosinophil counts of at the very least 300 cells per μL) and not using a historical past of bronchial asthma.

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