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Multi-omics analysis identified IL-4-induced IL1RL1high eosinophils characterized by prominent cysteinyl leukotriene metabolism

Continual rhinosinusitis and eosinophilic bronchial asthma are characterised by inflammatory responses involving eosinophils, with interleukin-4 (IL-4) recognized as a key mediator. Nevertheless, the exact mechanisms by which IL-4 influences eosinophil perform stay unclear, presenting a data hole hindering the event of focused therapies for these allergic circumstances. On this examine, we investigated the direct results of IL-4, a kind 2 cytokine, on human eosinophils, notably within the context of persistent rhinosinusitis and eosinophilic bronchial asthma.

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