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Meta-analysis of ACE inhibitor–induced angioedema identifies novel risk locus

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Angioedema is a uncommon however doubtlessly life-threatening opposed drug response in sufferers receiving angiotensin-converting enzyme inhibitors (ACEis). Analysis means that susceptibility to ACEi-induced angioedema (ACEi-AE) entails each genetic and nongenetic danger elements. Genome- and exome-wide research of ACEi-AE have recognized the primary genetic danger loci. Nonetheless, understanding of the underlying pathophysiology stays restricted.

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