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Mepolizumab incompletely suppresses clinical flares in a pilot study of episodic angioedema with eosinophilia

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Episodic angioedema with eosinophilia (EAE) is a uncommon multilineage cyclic syndrome of unknown etiology characterised by episodes of angioedema, myalgia, fatigue, and fever that happen each 3 to eight weeks and resolve between episodes with out remedy. Cyclic elevations in serum IL-5 ranges and neutrophils precede the rise in absolute eosinophil rely (AEC) in most sufferers.

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