Long-term prophylactic treatment with deucrictibant for angioedema due to acquired C1-inhibitor deficiency

Angioedema because of acquired C1-inhibitor deficiency (AAE-C1INH) is a uncommon dysfunction characterised by recurrent episodes of angioedema because of extreme bradykinin launch. Deucrictibant, an oral B2 receptor antagonist, is at the moment underneath improvement for long-term prophylactic and on-demand therapy in hereditary angioedema. In a latest, small, double-blind, placebo-controlled, crossover trial (EudraCT quantity, 2021-000720-36), all three individuals with AAE-C1INH had full management of angioedema throughout eight weeks of therapy with deucrictibant immediate-release capsule.

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