Interplay between on-demand treatment trials for hereditary angioedema and treatment guidelines

Over the previous 20 years, tips for the on-demand remedy of hereditary angioedema (HAE) assaults have undergone important evolution. Early remedy tips, such because the Canadian 2003 Worldwide Consensus Algorithm, usually gated on-demand remedy by assault location and/or severity. Pivotal trials for on-demand injectable therapies (plasma-derived C1 esterase inhibitor [C1INH], icatibant, ecallantide [US only], recombinant C1INH), which have been accredited within the US and EU between 2008–2014, have been designed accordingly.

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