Interactions between skin-resident dendritic and Langerhans cells and pain-sensing neurons

Numerous immune cells within the pores and skin contribute to its perform as a primary line of defence towards an infection/illness, whereas its dense innervation by pain-sensing sensory neurons protects the host from damage/harm alerts. Dendritic cells (DCs) are a heterogeneous inhabitants of cells that hyperlink the innate immune response to the adaptive response by capturing, processing, and presenting antigens to advertise T-cell differentiation and activation. DCs are considerable throughout peripheral tissues, together with the pores and skin, the place they’re discovered within the dermis and dermis.

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