Inter-Alpha-Trypsin Inhibitor Heavy Chain 4 (ITIH4) as a Compensatory Protease Inhibitor in Hereditary Angioedema (HAE)

Hereditary angioedema (HAE) is a genetic dysfunction that manifests as recurrent angioedema assaults, most regularly as a consequence of absent or diminished C1 inhibitor (C1-INH) exercise. C1-INH is a vital regulator of enzymatic cascades within the complement, fibrinolytic, and make contact with techniques. Inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) is an considerable plasma protease inhibitor that may inhibit enzymes within the proteolytic pathways related to HAE. Nothing is thought about its position in HAE.

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