Our understanding of the complement system continues to develop past that of a liver-derived systemically operative mechanism of pathogen clearance to a central orchestrator of single cell habits and tissue biology. These expanded actions replicate the extra-hepatic and native manufacturing of complement by many, if not most, cells, and the surprising current discovering that complement additionally serves vital physiological intracellular roles. The complement core element C3 has emerged as a very essential participant in primary cell features.
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